Eight years after the events of BioShock, the Big Sisters are post-pubescent Little Sisters who have become unstable and confrontational in Rapture's environment. They interact with, manage and protect Little Sisters. Their extreme level of powers go far beyond that of normal Plasmid users, and might be attributed to their growing bodies adapting to the ADAM created in their bodies as children. Thus, they have a much greater natural affinity for the powers that ADAM creates.
|Big Sister ● Booker DeWitt ● Cornelius Slate ● Eleanor Lamb ● Elizabeth ● J.S. Steinman ● Little Sister ● Subject Delta|